Sickle Cell Clinics & Specialists
South Carolina is home to several leading sickle cell care programs. Families can access care through dedicated Sickle Cell Lifespan Clinics at Prisma Health (Columbia and Greenville) and the Rena N. Grant Sickle Cell Center at MUSC in Charleston. These clinics bring together hematologists, nurse practitioners, social workers, and patient navigators who specialize in sickle cell disease.
Please Note: Rise SC does not provide direct services.
Each listing links you directly to the organization offering support.
Prisma Health Sickle Cell Lifespan Center – Upstate
📍 900 W. Faris Rd., 2nd Fl., Greenville, SC 29605 •
☎️ (864) 455-8898
A true multi-disciplinary lifespan center offering medical, psychosocial, infusion, transfusion, TCD stroke screening, transition support, research access, and innovative therapies like VR and peer support programs.
Bon Secours Hematology & Oncology (Greenville)
📍 104 Innovation Dr., Ste. 2000, Greenville, SC 29607 •
☎️ (864) 603-6300
Hematology-oncology practice offering comprehensive care with social work and disease-modifying therapies.
Upstate of South Carolina
Sickle Cell Lifespan Center – Midlands (Youth)
📍 Columbia, SC • Contact: 803-434-3533 •☎️1-800-775-2287
A children’s hospital offering outreach clinics across communities.
Prisma Health Sickle Cell Lifespan Center (Adults)
📍 3010 Farrow Rd, Suite 200, Columbia, SC 29203 •
☎️ (803) 434-6100
A “medical home” providing primary and sickle cell care to adults, plus infusion services at Suite 110 for hydration, transfusions, and patient-centered support.
Prisma Health Infusion Center – Columbia
📍 3010 Farrow Rd., Suite 110, Columbia, SC 29203 •
☎️ (803) 434-3650
Provides compassionate, comfortable specialty infusions—including IV hydration and blood products—serving Columbia, Lexington, and surrounding Midlands areas with hospitality and personalized care.
Midlands of South Carolina
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MUSC Children’s Health — Pediatric Sickle Cell Center (Charleston)
📍 Shawn Jenkins Children's Hospital + Pearl Tourville Women's Pavilion (10 McClennan Banks Drive, Charleston, SC 29425)
☎️ (843) 876-0444
Multidisciplinary pediatric care including acute management, preventive treatment, coordination, and access to pediatric specialists.
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Rena N. Grant Sickle Cell Center
📍 Rutledge Tower, 135 Rutledge Ave, Charleston, SC 29425 • ☎️ (843) 876-0888
Comprehensive adult care including preventive services, pain management, research options, psychological support, and pharmacy services.
Lowcountry of South Carolina
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DPH Sickle Cell Disease Program (CYSHCN Services)
📍 South Carolina Department of Public Health •
☎️ (803) 898-0784
Provides care coordination, nursing, nutrition, and social work consultation, as well as assistance with payment for eligible medical services and supplies for individuals living with sickle cell disease.
SC Sickle Cell Disease Registry
📍 South Carolina Department of Public Health •
A voluntary statewide registry designed to connect patients, caregivers, and providers while supporting better care coordination, research, and policy development for sickle cell disease.
State-Level Services & Programs
Don’t See Your Organization Listed?
Rise SC is always growing — and we know there are more incredible organizations, programs, and support groups across South Carolina doing important work in chronic disease care.
If your organization provides services, education, or community support for families living with sickle cell or other chronic conditions, we’d love to include you.
Next Steps
Once reviewed, our team will reach out if we need additional information before adding it to the directory.
Together, we can make sure every family finds the help, hope, and connection they need.