Nonprofit & Foundation Directory
South Carolina is home to incredible nonprofits and foundations dedicated to supporting individuals and families living with sickle cell disease. This directory brings them together in one place, making it easier for families to connect with trusted community programs, support groups, and services.
Please Note: Rise SC does not provide direct services.
Each listing links you directly to the organization offering support.
Upstate of South Carolina
L.D. Barksdale Sickle Cell Anemia Foundation
📍 645 South Church St., Spartanburg, SC • ☎️ (864) 582-9420
Serving the Upstate and Midlands since 1974, the Foundation supports individuals and families impacted by sickle cell disease through care, education, and advocacy.
Services include:
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Free sickle cell trait testing & counseling
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Limited emergency financial assistance (medications, utilities, transport)
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Monthly support group meetings with education & peer support
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Family and community events (picnics, holiday gatherings)
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Referrals for mental health and social services
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Educational resources and care navigation
Midlands of South Carolina
James R. Clark Memorial Sickle Cell Foundation
📍 1420 Gregg St., Columbia, SC •
☎️ (800) 506-1273
(Additional satellite offices in Florence, Lancaster, and Sumter)
A United Way agency serving families in need of sickle cell assistance across 15 Midlands and Upper South Carolina counties.
Services Include:
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Newborn and genetic screening & counseling (free, confidential testing of infants and carriers)
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Nurse case management, emergency client assistance, and support groups for children (“Little Wonders”) and adults/parents
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Education and outreach for clients, professionals, and the community
The B Strong Group
📍 Columbia, SC • 🌐 thebstronggroup.org
The B Strong Group a 501(c)(3) founded to raise awareness about sickle cell disease through education, caregiver support, and blood donation drives. Their programs empower families and strengthen communities impacted by sickle cell across South Carolina.
Services Include:
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Community education and awareness campaigns, including organizing blood drives
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Care package donations (e.g., blankets, hygiene items) to adult patients receiving care at local infusion centers like Prisma Health
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Events such as the annual South Carolina Sickle Cell Symposium
Lowcountry/ Pee Dee
COBRA Human Services Agency – Sickle Cell Program
📍 3962 Rivers Ave., Charleston, SC • ☎️ (800) 354-4704
Serving the Lowcountry, COBRA provides counseling, patient navigation, and community education to support families impacted by sickle cell disease.
Services Include:
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Education and resource-sharing on sickle cell disease
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Advocacy efforts, including voter registration and broader community health partnerships
Orangeburg Area Sickle Cell Foundation
📍 825 Summers Ave., Orangeburg, SC • ☎️ (803) 534-1716
A rural-serving nonprofit to boost education and access to care for those affected by sickle cell disease.
Services Include:
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Holistic support (addressing physical, mental, and emotional well-being)
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Educational programs, utilities support, medication assistance, food assistance, screening, and counseling for individuals, families, schools, churches, businesses
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Community engagement and advocacy to raise awareness and reduce stigma
The Riley Foundation for Sickle Cell Disease
📍 291 Highway 90 East, Suite D, Little River, SC •☎️ (843) 281-1390
Based in Little River, the Riley Foundation serves Horry, Georgetown, and Charleston counties and provides education, advocacy, and community resources for families living with sickle cell disease.
Services Include:
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Education and awareness (trait awareness, testing, outreach, myth-busting)
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Medical connections (blood drives, bone marrow registration, emergency and holiday support)
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Community Outreach- Annual blood drives, bone marrow registration initiatives, and direct support for sickle cell families, including holiday assistance and emergency resources.
Sickle Cell Disease Association of America (SCDAA)
📍 National Headquarters (serves SC statewide) •☎️ (410) 528-1555
The leading national organization advocating for funding, research, and community services; provides education, resources, and program support for local SC foundations.
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Sickle Cell Partners of the Carolinas
📍 Serving North & South Carolina •
🌐 sicklecellpartnersofthecarolinas.org
A regional nonprofit advancing awareness, education, and advocacy across the Carolinas, connecting patients, families, and healthcare professionals to resources and support networks.
Support & Advocacy Coalitions (National & Statewide)
Don’t See Your Organization Listed?
Rise SC is always growing — and we know there are more incredible organizations, programs, and support groups across South Carolina doing important work in chronic disease care.
If your organization provides services, education, or community support for families living with sickle cell or other chronic conditions, we’d love to include you.
Next Steps
Once reviewed, our team will reach out if we need additional information before adding it to the directory.
Together, we can make sure every family finds the help, hope, and connection they need.